- What is ImmunoD® ATSM?
- What does Vitamin D have to do with autism?
- What does oxidative stress have to do with autism?
- Why Vitamin D substitution?
- What is a medical dietary?
- Field experience
- When and how to use?
- List of references
What is ImmunoD® ATSM?
ImmunoD® ATSM is a special purpose dietary supplement (balanced diet) based on the latest scientific knowledge and tailored to the metabolic needs of ASD children. The Vitamin D used is not the conventional liposoluble form (cholecaliciferol) but a new one that gets water-soluble via an innovative patented process and is thereby clearly better available for the body.
What does Vitamin D have to do with autism?
While Vitamin D is known to be relevant to bone health, evidence of its effects on mental health has recently emerged. To understand the potential benefits and limitations of vitamin D for mental health, understanding the physiology of vitamin D, the limits of vitamin D deficiency, and the current status of therapeutic trials are of paramount importance (1). Overall, results from 25 cross-sectional studies and 8 longitudinal studies indicate a role for Vitamin D in the pathogenesis of childhood and adolescent mental disorders (1). Increasing evidence points to the possibility that childhood pregnancy deficiency and Vitamin D deficiency can cause some cases of autism. Vitamin D is converted into a secretory hormone that regulates about 3% of the 26,000 genes in the coding human genome. It is also a neurosteroid that is active in brain development and has effects on cell proliferation, differentiation, calcium signalling, neurotrophic and neuroprotective effects. It also appears to have an impact on neurotransmission and synaptic plasticity. Children on the autism spectrum have lower levels of 25 (OH) D than their unaffected siblings at the age of 3 months, at birth, and at the age of 8 years. In two open studies, high-dose Vitamin D has been shown to improve the core symptoms of autism in about 75% of autistic children. Some improvements were remarkable (2).
What does oxidative stress have to do with autism?
Studies indicate increased oxidative stress in autism, which may contribute to the development of this disorder. What is oxidative stress? Oxidative stress refers to a metabolic situation in which a large amount of reactive oxygen species (ROS - reactive oxygen species) is formed or is present. These reactive oxygen compounds are generated during metabolic processes of the mitochondrial electron transport chain and cytochrome P450 oxidases. Normal cells in the organism maintain their ability to neutralize reducing or oxidizing substances by producing and storing oxidizing or reducing substances. An imbalance between these pools overstretches the normal repair and detoxification function of a cell, and thus can damage all cellular and extracellular macromolecules. This is called oxidative stress. Environmental and genetic factors may increase susceptibility to oxidative stress in those with autism spectrum disorders (6).
Why Vitamin D substitution?
Overall, results from 25 cross-sectional studies and 8 longitudinal studies indicate a role for Vitamin D in the pathogenesis of childhood and adolescent mental disorders (1). Vitamin D is converted into a secretory hormone that regulates about 3% of the 26,000 genes in the coding human genome. It is also a neurosteroid that is active in brain development and has effects on cell proliferation, differentiation, calcium signalling, neurotrophic and neuroprotective effects. It also appears to have an impact on neurotransmission and synaptic plasticity. Children on the autism spectrum have lower levels of 25 (OH) D than their unaffected siblings at the age of 3 months, at birth, and at the age of 8 years. In two open studies, high-dose Vitamin D has been shown to improve the core symptoms of autism in about 75% of autistic children. Some improvements were remarkable (2). Dependent on parameters, measuered at above-mentioned studies, an oral substitution of vitamin D can improve symptoms of ASD and can therefore be recommended (1-12). 1. Krisanova, N., N. Pozdnyakova, A. Pastukhov, M. Dudarenko, O. Maksymchuk, P. Parkhomets, R. Sivko, and T. Borisova. 2019. Vitamin D3 deficiency in puberty rats causes presynaptic malfunctioning through alterations in exocytotic release and uptake of glutamate/GABA and expression of EAAC-1/GAT-3 transporters. Food Chem Toxicol 123: 142-150. 2. Chauhan, N., S. K. Padhy, R. Shah, and S. Malhotra. 2019. Vitamin D Deficiency in Children with Psychiatric Illness in a Tertiary Care Hospital in North India. J Neurosci Rural Pract 10: 16-20. 3. Alzghoul, L., L. N. Al-Eitan, M. Aladawi, M. Odeh, and O. Abu Hantash. 2019. The Association Between Serum Vitamin D3 Levels and Autism Among Jordanian Boys. J Autism Dev Disord 4. George, A. S., M. C. Mathew, A. Mathew, S. S. Jacob, and J. M. Raj. 2019. Prevalence and Risk Factors of Hypovitaminosis-D in Children with Cognitive and Movement Disorders. Indian J Pediatr 5. García-Serna, A. M., and E. Morales. 2019. Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis. Mol Psychiatry 6. Mazahery, H., C. A. Conlon, K. L. Beck, O. Mugridge, M. C. Kruger, W. Stonehouse, C. A. Camargo, B. J. Meyer, B. Jones, and P. R. von Hurst. 2019. A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder. J Steroid Biochem Mol Biol 187: 9-16. 7. Turley, J. W., and T. W. Harding. 2018. Vitamin D supplementation and core symptoms of autism? Potential more than promise given study limitations. J Paediatr Child Health 54: 926. 8. McKinnon, I., T. Lewis, N. Mehta, S. Imrit, J. Thorp, and C. Ince. 2018. Vitamin D in patients with intellectual and developmental disability in secure in-patient services in the North of England, UK. BJPsych Bull 42: 24-29. 9. Berridge, M. J. 2018. Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia). Am J Physiol Cell Physiol 314: C135-C151. 10. Guo, M., J. Zhu, T. Yang, X. Lai, Y. Lei, J. Chen, and T. Li. 2018. Vitamin A and vitamin D deficiencies exacerbate symptoms in children with autism spectrum disorders. Nutr Neurosci 1-11. 11. Anjum, I., S. S. Jaffery, M. Fayyaz, Z. Samoo, and S. Anjum. 2018. The Role of Vitamin D in Brain Health: A Mini Literature Review. Cureus 10: e2960. 12. Altun, H., E. B. Kurutaş, N. Şahin, O. Güngör, and E. Fındıklı. 2018. The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders. Clin Psychopharmacol Neurosci 16: 383-390.
What is a medical dietary?
Dietary food for special medical purposes (balanced diet) is a particular classification of edibles, which need to satisfy legal criteria and to be prooven by scientific data. Balanced diet is a form of concomitant, but not preventive therapy for patients with special needs caused by illness, pain or other medical condition. Legislation clearly regulates labeling obligations and allowed ingredients. Balaced diet should e prescribed and administeres by physicians. Dietary food for special medical purposes are no pharmaceutical products or medicine.
Field experience
“Over 160 children with ASD are receiving ImmunoD® ATSM worldwide – with good results."
When and how to use?
Every other day, fill the ampoule halfway with water, close the ampoule and shake the contens carefully for 45 seconds. It is consumed by oral ingestion, whereby the amount of liquid should remain for 3 minutes in the mouth before swallowing it. Do not administer in conjunction with a meal.
List of references
1. Föcker, M., J. Antel, S. Ring, D. Hahn, Ö. Kanal, D. Öztürk, J. Hebebrand, and L. Libuda. 2017. Vitamin D and mental health in children and adolescents. Eur Child Adolesc Psychiatry 26: 1043-1066. 2. Cannell, J. J. 2017. Vitamin D and autism, what’s new. Rev Endocr Metab Disord 18: 183-193. 3. Rommer, P. S., J. Greilberger, S. Salhofer-Polanyi, E. Auff, F. Leutmezer, and R. Herwig. 2014. Elevated levels of carbonyl proteins in cerebrospinal fluid of patients with neurodegenerative diseases. Tohoku J Exp Med 234: 313-317. 4. Rommer, P. S., D. Fuchs, F. Leblhuber, R. Schroth, M. Greilberger, E. Tafeit, and J. Greilberger. 2016. Lowered Levels of Carbonyl Proteins after Vitamin B Supplementation in Patients with Mild Cognitive Impairment and Alzheimer’s Disease. Neurodegener Dis 16: 284-289. 5. Greilberger, J., M. Greilberger, and R. Herwig. 2017. Measurement of oxidative stress parameters, vitamin D and vitamin D binding protein during vitamin D treatment in a patient with amyotrophic lateral sclerosis. Integr Mol Med 4: 1-5. 6. Chauhan, A., and V. Chauhan. 2006. Oxidative stress in autism. Pathophysiology 13: 171-181. 7. Chauhan, A., V. Chauhan, W. T. Brown, and I. Cohen. 2004. Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin--the antioxidant proteins. Life Sci 75: 2539-2549. 8. Saad, K., A. A. Abdel-Rahman, Y. M. Elserogy, A. A. Al-Atram, A. A. El-Houfey, H. A. Othman, G. Bjørklund, F. Jia, M. A. Urbina, M. G. M. Abo-Elela, F. A. Ahmad, K. A. Abd El-Baseer, A. E. Ahmed, and A. M. Abdel-Salam. 2018. Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder. J Child Psychol Psychiatry 59: 20-29. 9. Greilberger, J., M. Greilberger, and R. Herwig . 2018. A Newly Developed Dimer of Vitamin D Combined with N-Acetylgalactosamin-Albumin Protein Carrier is a Safe and Conciliable Method to Rapidly Provide …. Curr Trends Biomedical Eng & Biosci 14: 1-6. 10. Greilberger, J., M. Greiberger, T. Petek, P. Stiegler, B. Leber, H. Reichl, A. Kamel, and R. Herwig. 2019. Effective Increase of Serum Vitamin D3 by IV Application of a Cholecalciferol-N-Acetyl-Galactosamine-Stabilized Dimer: a Clinical Murine Trial Study. Clin Lab 5: 11. Pfannhauser, W., and D. Pfannhauser. 2009. Definitionen und Abgrenzungsproblematik: Was sind diätetische Lebensmittel? Ernährung/nutrition 33: 215. 1. Basheer, S., A. Natarajan, T. van Amelsvoort, M. M. Venkataswamy, V. Ravi, S. Srinath, S. C. Girimaji, and R. Christopher. 2017. Vitamin D status of children with Autism Spectrum Disorder: Case-control study from India. Asian J Psychiatr 30: 200-201. 2. Bauman, M. D., A. M. Iosif, P. Ashwood, D. Braunschweig, A. Lee, C. M. Schumann, J. Van de Water, and D. G. Amaral. 2013. Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey. Transl Psychiatry 3: e278. 3. Bener, A., A. O. Khattab, D. Bhugra, and G. F. Hoffmann. 2017. Iron and vitamin D levels among autism spectrum disorders children. Ann Afr Med 16: 186-191. 4. Berridge, M. J. 2018. Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia). Am J Physiol Cell Physiol 314: C135-C151. 5. DeLuca, G. C., S. M. Kimball, J. Kolasinski, S. V. Ramagopalan, and G. C. Ebers. 2013. Review: the role of vitamin D in nervous system health and disease. Neuropathol Appl Neurobiol 39: 458-484. 6. Diagnostic, A. P. A. 2000. Diagnostic and Statistical Manual of Mental Disorders, Text Revision. American Psychiatric Association, 7. El-Ansary, A., S. Al-Daihan, A. Al-Dbass, and L. Al-Ayadhi. 2010. Measurement of selected ions related to oxidative stress and energy metabolism in Saudi autistic children. Clin Biochem 43: 63-70. 8. Frackowiak, J., B. Mazur-Kolecka, N. C. Schanen, W. T. Brown, and J. Wegiel. 2013. The link between intraneuronal N-truncated amyloid-β peptide and oxidatively modified lipids in idiopathic autism and dup(15q11.2-q13)/autism. Acta Neuropathol Commun 1: 61. 9. Guo, M., J. Zhu, T. Yang, X. Lai, Y. Lei, J. Chen, and T. Li. 2018. Vitamin A and vitamin D deficiencies exacerbate symptoms in children with autism spectrum disorders. Nutr Neurosci 1-11. 10. Gvozdjáková, A., J. Kucharská, D. Ostatníková, K. Babinská, D. Nakládal, and F. L. Crane. 2014. Ubiquinol improves symptoms in children with autism. Oxid Med Cell Longev 2014: 798957. 11. Kočovská, E., F. Gaughran, A. Krivoy, and U. C. Meier. 2017. Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism. Front Psychiatry 8: 47. 12. Lerner, P. P., L. Sharony, and C. Miodownik. 2018. Association between mental disorders, cognitive disturbances and vitamin D serum level: Current state. Clin Nutr ESPEN 23: 89-102. 13. McKinnon, I., T. Lewis, N. Mehta, S. Imrit, J. Thorp, and C. Ince. 2018. Vitamin D in patients with intellectual and developmental disability in secure in-patient services in the North of England, UK. BJPsych Bull 42: 24-29. 14. Máčová, L., M. Bičíková, D. Ostatníková, M. Hill, and L. Stárka. 2017. Vitamin D, neurosteroids and autism. Physiol Res 66: S333-S340.
2-3 days
Ingredients
| Quantity | Content per ampoule | per 100 ml |
| Galaktose (-PAGA) | 200 mg | 20 g |
| Trehalose | 200 mg | 20 g |
| Fat | - | - |
| Carnosin | 50 mg | 5 g |
| Mg-2-oxoglutarat | 3 mg | 0,3 g |
| Vitamin D3 (Cholecalciferol)* | 25µg | 2,5 mg |
Nutrition information: average nutritional value per 100 ml
| pro Ampulle | pro 100 ml | |
| Calorfic value | 7,3 kJ/1,7 kcal | 730 kJ/170 kcal |
| Fat | 0 mg | 0 g |
| Thereof saturated fatty acid | 0 mg | 0 g |
| Carbohydrates | 403 mg | 40,3 g |
| Sugar | 400 mg | 40 g |
| Protein | 50 mg | 5 g |
| Salt | 0 mg | 0 g |
Warnings
To be applied only under medical supervision. Suitable for children from 6 years. Not suitable as sole food source. A health hazard in teh event of improper use has not been observed to date. During pregnancy or lactation please consult a doctor.
Storage
Store in a cool, dry place at room temperature (15-24° C). Keep outside the reach of small children.