Caution: Science! What does AKG do in our bodies?
Alpha-ketoglutarate (αKG) is a key intermediate of the citric acid cycle (Krebs cycle), which is crucial for energy production in cells. It plays an essential role in carbohydrate metabolism and energy production, formed in the mitochondria from isocitrate by isocitrate dehydrogenase. In addition, αKG serves as a nitrogen transporter in amino acid metabolism and is therefore essential for protein synthesis.
One of the best-known effects of αKG is its antioxidant capacity. Through its ability to neutralize harmful free radicals, αKG contributes to reducing oxidative stress in cells. This is particularly important in relation to age-related diseases such as neurodegenerative diseases or cardiovascular problems.
Furthermore, several studies have shown that αKG is involved in the regulation of epigenetic modifications, particularly through its function as a cofactor of dioxygenases that promote DNA demethylation. This process plays an important role in the control of gene expression and is increasingly implicated in aging and cancer development.
αKG has also been studied in connection with promoting longevity. Animal studies, particularly in C. elegans, have shown that αKG can extend lifespan by inhibiting signals that promote aging. It has also been shown that αKG supports anabolic metabolism in muscle, which is particularly important for muscle maintenance in old age.
In summary, αKG is a versatile molecule with potential applications in cancer research, the management of age-related diseases, and the support of muscle and metabolic health. Researchers worldwide are working to further explore the precise role of αKG in various biological processes.
One of the best-known effects of αKG is its antioxidant capacity. Through its ability to neutralize harmful free radicals, αKG contributes to reducing oxidative stress in cells. This is particularly important in relation to age-related diseases such as neurodegenerative diseases or cardiovascular problems.
Furthermore, several studies have shown that αKG is involved in the regulation of epigenetic modifications, particularly through its function as a cofactor of dioxygenases that promote DNA demethylation. This process plays an important role in the control of gene expression and is increasingly implicated in aging and cancer development.
αKG has also been studied in connection with promoting longevity. Animal studies, particularly in C. elegans, have shown that αKG can extend lifespan by inhibiting signals that promote aging. It has also been shown that αKG supports anabolic metabolism in muscle, which is particularly important for muscle maintenance in old age.
In summary, αKG is a versatile molecule with potential applications in cancer research, the management of age-related diseases, and the support of muscle and metabolic health. Researchers worldwide are working to further explore the precise role of αKG in various biological processes.